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Clinician’s Corner: Pyridoxine or Vitamin (B6)

Your Thompson Pharmacist will take to our next B vitamin: Pyridoxine or Vitamin (B6)

Sources of B6:  meat, fish, legume, dry yeast, potatoes and other starchy vegetables and non-citrus fruits.

Function: helps with essential reactions in the metabolism of certain amino & fatty acids.  Vitamin B6  is involved in more than 100 enzyme reactions, mostly concerned with protein metabolism

Deficiency States: may lead to anemia, convulsions in infants, cracked lips, seborrhea like skin reactions and nerve pain/tingling.  Dialysis patients, and those deficient in other B-vitamins are more likely to express symptoms of Vitamin-B-6 deficiency.

Treatment of Nausea of Pregnancy:

DICLEGIS:  a fixed dose combination drug product (Delayed-release tablets containing 10mg doxylamine succinate and 10 mg pyridoxine hydrochloride).

Dose:  Take two tablets daily at bedtime. The dose can be increased to a maximum recommended dose of four tablets daily (one in the morning, one mid-afternoon and two at bedtime) (cost: almost $600.00/ 100 tablets).

Many OB/GYN physicians will recommend Vitamin B-6 and Doxylamine for treatment of nausea of pregnancy. Patients can find doxylamine under the brand name of Unisom SLEEPTABS 25mg, and have patients split in half.  Make sure they are the SLEEPTABS, and not other Unisom formulations that contain diphenhydramine. Vitamin B6 (pyridoxine) is kept in the vitamin section of Thompson Pharmacy.

Supplement B-6 with the following drugs that DEPLETE Vitamin B-6: Have your Thompson Pharmacist check your medication list.

    • Isoniazid- (a tuberculosis drug)
    • Birth Control pills
    • Long Term corticosteroid use (like prednisone)
    • Loop diuretics (powerful water pills like Lasix (furosemide)
    • Phenytoin, carbamazepine (two seizure drugs known as Dilantin and Tegretol)

B-6 and Chinese Restaurant Syndrome: Proper metabolism of Monosodium Glutamate (MSG) requires sufficient vitamin B6. Supplementation may eliminate symptoms which often include headache, skin flushing, and sweating.

Kidney stones: Vitamin B6 and magnesium supplementation can prevent calcium oxalate kidney stones in patients predisposed to forming these stones.

Consult your Thompson Pharmacist for any questions about Vitamin B-6, or any other vitamin supplement. Go ahead and ASK, at Thompson Pharmacy it’s all for YOU!