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Clinician’s Corner: Insulin

HISTORY:  Frederick Banting (who was an orthopedic surgeon), Charles Best, James Collip, and John Macleod are credited with the monumental discovery of insulin at the University of Toronto in 1922.  The discovery was followed shortly after by the successful large-scale production of insulin in 1923 by the USA company...

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Clinician’s Corner: DPP4  INHIBITORS

DPP4  INHIBITORS— not very potent and very expensive! Incretins that we naturally produce blunt glucagon release (which raises blood sugars)  and stimulate insulin release when blood sugars are elevated.  Incretins, released in response to a meal, also slow digestion and promote a feeling of fullness. We have an enzyme...

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Clinician’s Corner: THIAZOLIDINEDIONES (“glitazones”) (“TZD’s”)

THIAZOLIDINEDIONES (“glitazones”) (“TZD’s”) Troglitazone (Rezulin) – removed from market in late 90’s due to drug induced hepatitis. Pioglitazone (Actos)-Available strengths= 15, 30 and 45mg (available generically rather inexpensive) Rosiglitazone (Avandia)= available strengths= 2,4,8mg Mechanism of TZD’s: work by increasing insulin sensitivity in fat and muscle tissue. main action occurs...

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